SINCE World War II, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in several people. It’s not pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall consider the various factors that decide the selection of a certain drug.
Safety: These sub-criteria has to be considered underneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug even when it’s certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but have the opportunity side-effect of addiction.
* Long-term safety: drug could be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals react to produce a different chemical, that have an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other person, have certain effects using one or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This causes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually generate the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the medicines are more serious.
Tolerability: A drug could be effective but not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability need to be considered. Efficacy: A drug is just not equally good at all patients. For instance, some patients with depression or panic disorders experience rest from escitalopram, but there are several that don’t, who therefore need to be prescribed a different anti-depressant. The interest rate of start of therapeutic action is a crucial factor to be considered too.
Cost: Cost does not mean the price of buying a specific medicine alone. It should also cover the price of treating a complication which could arise by using a different drug. Example: Within a individual that insists on taking alcohol and yet has to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (including tricyclics) might cause a brand new overuse injury in such patients, which could require a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.
Simple treatment: The best mode of administration is preferred. If you find an option between a shot and oral administration, aforementioned is preferred if the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to determine simple treatment.
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