SINCE World war 2, medical science has progressed with a stage where competitive medications are around to treat the identical ailment in numerous people. It’s not almost brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall glance at the various factors that decide picking a a certain drug.
Safety: The subsequent sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug even though it’s got certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medicine directory might be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals answer produce a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects using one or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This makes more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually make the same relation to the identical organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two medicine is more serious.
Tolerability: A medicine might be effective but not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability need to be taken into account. Efficacy: A medicine just isn’t equally effective in all patients. For example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are numerous that do not, who therefore need to be prescribed some other anti-depressant. The pace of onset of therapeutic action is an important step to be looked at too.
Cost: Cost does not mean the cost of acquisition of a certain medicine alone. It will also cover the cost of treatment of a complication that may arise by using some other drug. Example: Within a person who insists on taking alcohol and yet should be treated for depression is often administered an SSRI drug because they drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (like tricyclics) could cause a whole new symptom in such patients, which could demand a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than a cheaper tricyclic in such patients.
Simple treatment: The easiest mode of administration is preferred. When there is an option between an injection and oral administration, the second is preferred in the event the efficacy of the two modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to determine simplicity of treatment.
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