SINCE The second world war, medical science has progressed to some stage where competitive medications are around to treat exactly the same ailment in several people. This isn’t just about brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall look at the various factors that decide picking a a specific drug.
Safety: The subsequent sub-criteria should be considered within the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective can be a particular drug regardless of whether it has certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: medicationdirectory.com could be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and many chemicals answer make a different chemical, that have an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This causes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same effect on exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the two prescription medication is more serious.
Tolerability: A drug could be effective however, not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability should be looked at. Efficacy: A drug is not equally great at all patients. For example, some patients with depression or panic attacks experience respite from escitalopram, but there are numerous who don’t, who therefore should be prescribed some other anti-depressant. The pace of onset of therapeutic action is a vital key to be regarded as too.
Cost: Cost does not always mean the cost of buying a particular medicine alone. It should also cover the cost of treating a complication that could arise from using some other drug. Example: Inside a person who insists on taking alcohol yet needs to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another group of anti-depressants (including tricyclics) might cause a new condition in such patients, which may need a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than cheaper tricyclic in these patients.
Simple treatment: The easiest mode of administration is preferred. If there is a choice between a shot and oral administration, the second is preferred when the efficacy of the two modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to choose simple treatment.
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